mthfr double mutation

[beccaleigh]

I have recently discovered both my dh and I have the same double mthfr mutation. I am on femara and am TTC. does anyone know about this, and if so are there any successful pregnancies?
becca leigh
(formerly rlm)

[grj]

Hi, Becca Leigh. I normally don't post on this board, but the post title caught my eye. I was diagnosed in July 04 with the double mutation (after 2 m/c's in 6 mos). One of the things that that my reproductive endocrinologist did after the diagnosis was to have me come in for a fasting blood draw. They use this to measure something called homocystene. Research has found that if you have elevated levels of homocystene and the mthfr double mutation, it can cause problems during pregnancy, not to mention other areas of your life. It can also be a contributing factor in heart disease and strokes, since it makes you more prone to blood clots. Standard treatment includes a daily baby asprin and a supplemental vitamin containing high doses of b6, b12 and folic acid. During pregnancy, some docs recommend daily heprin (a blood thinner) injections.

Succesfull pregnancies are possible. I have a 6 yr old son and a 4 yr old dr and had no clue that I had this mutation until I had back to back losses. Since my mom and my sister were also diagnosed with the double mutation, it stands to reason that I've probably had this for quite a while. One of my dear friends, who has two daughters close to my kids in age. lost a baby at 24 weeks in March 04 due to MTHFR. Needless to say, she had no clue she had mthfr until she lost her son. However, I am happy to report that she gave birth 2 weeks ago to another son at 36 weeks and both of them are just fine. I myself am currently 22 weeks pregnant and hope to share the same happy ending. So - just wanted to give you some hope. I don't know your story, but I am glad that you found out now. That way, when you finally get that BFP, your doc will be forewarned and will monitor you more closely than would be expected for the general population. I've included a good link that explains MTHFR more in depth. It can be hard to chew through the medical terms, but if you print it out, your doc will probably decode it for you. I wish you the best of luck. Gina

www.fetal-medicine.com/MTHFR.htm

PS. One more thing - my sister's doc told her that due to MTHFR, she should not be on ANY hormone based birth control (the pil, the patch , the ring, etc) ever again because it increases the chances of a blood clot on top of what the MTHFR already does. I know this is not an issue you are facing now since you are TTC, but I thought it was something you may want to talk to your dr about.