I don't know what that is. I am heterozygous (1 gene mutation) for a blood clotting condition MTHFR and it required me to not only be on aspirin, but heparin injections, extra folic acid and prednisone, in order to carry my last two.
Mother to 5 sweet babies in Heaven and 3 on earth...
I do not have this mutation, but once you have known me for long you will find that if you give me a medical puzzle, i'll research it to death.
This particular mutation puts you at higher risk for thrombosis (blood clots). In particular, it puts you at higher risk for "microclots" early in pregnancy, where you miscarry the baby very early on because the tiny vessels forming in the trophoblast get clotted off before the placenta has much of a chance to develop. This matches pretty strongly with your m/c history. In your shoes, I would be pushing for a low dose of heparin/lovenox as well. Of course you have to go with what you are comfortable with (and I am not a doctor), but looking at the research and your history, I would push a bit for further treatment.
Incidentally, if you ever go in for surgery etc. in the future, the surgeon should be aware of this diagnosis. This particular mutation puts you at greater risk for thrombosis after surgery, as well. I would probably consult with a hematologist to be sure there is not more you need to do (such as low dose aspirin outside of pregnancy).
Given your early m/c history, I would be sure you are taking a low dose aspirin daily throughout your cycle so that when implantation occurs you already have some protection from clotting. I agree that this is a point of controversy among doctors, but with your m/c history, I would lean toward pushing for a more aggressive approach.
DH since 1996 Melissa 5/97, Jessica 8/98, Cassandra 7/00, Hyrum 09/01, Seth 2/05, Noah 7/06, and our miracle Sophia 06/09 5 miscarriages: Feb. 04, Aug. 07, Feb. 08, May 08, and Mar. 10
Post by sunshine10 on Nov 19, 2010 17:39:53 GMT -5
Thanks so much for doing the research. You answered a lot of my questions. Most of the info about it is in research papers which I don't have the patience to sift through. I will look more into this with my doc. I have a tendency to bruise easily so I wonder if this mutation has anything to do with it.....